abstract：:Experimental manganese lymphadenopathy was produced by guinea pigs by intratracheal inoculation of manganese dioxide (50 mg/300 g body weight) and histopathologic changes in the tracheobronchial lymph nodes were studied up to 180 days. There was slow extracellular transport of manganese dust into the nodes, which did ...

journal_title：Archives of toxicology

authors： Shanker R,Dogra RK,Sahu AP,Zaidi SH

更新日期：1976-10-28 00:00:00

abstract：:A pharmacokinetic profile of [14C] leptophos was determined in laying hens following a single oral dose of 400 mg/kg (0.58 muCi). Most of the radioactivity was excreted into the urine and feces. After 15 days, the total radioactivity recovered in the combined urinary-fecal excretion was 73.5% of the administered dose....

journal_title：Archives of toxicology

authors： Abou-Donia MB

更新日期：1976-10-28 00:00:00

abstract：:A method is described for the determination of lorazepam plasma levels involving extraction from the sample and analysis of the intact lorazepam by electron capture gas-liquid chromatography. Using mass spectrometry it is demonstrated, that lorazepam shows a thermal rearrangement under gas chromatographic conditions. ...

journal_title：Archives of toxicology

authors： de Groot G,Maes RA,Lemmens HH

更新日期：1976-06-08 00:00:00

abstract：:Phenobarbital pretreatment (50 mg/kg/day for 3 days orally) of male Wistar rats increased Vmax of benzene in vitro hepatic microsomal biotransformation about 6-fold without changing Km. However, benzene blood levels after oral, intraperitoneal, or subcutaneous benzene administration (3-3.5 mmoles/kg) were not influenc...

journal_title：Archives of toxicology

authors： Gut I

更新日期：1976-06-08 00:00:00

abstract：:In female rats, the lethality and hepatotoxicity of cerous chloride (CeCl3) were significantly altered by pretreatment with steroidal and nonsteroidal compounds (pregnenolone-16alpha-carbonitrile "PCN", dexamethasone, spironolactone, phenobarbital) that stimulate hepatic drug-metabolizine enzyme activity and by estrad...

journal_title：Archives of toxicology

authors： Salas M,Tuchweber B

更新日期：1976-03-11 00:00:00

abstract：:In female rats dosed orally with 14C-hexachlorobenzene the extent of intestinal absorption of carbon-14 has been found to be dependent on the form of application. When the substance was given as a solution in oil about 80% of the dose administered was absorbed, but when given as an aqueous suspension only 6%. In anima...

journal_title：Archives of toxicology

authors： Koss G,Koransky W

更新日期：1975-11-20 00:00:00

abstract：:Delta 9-THC at the dose of 1 mg/kg/die was administered subcutaneously in growing rats, from the second to the 30th day of life. A statistically significant myeloid hyperplasia was demonstrated, which persisted up to 4 months after the end of the treatment, together with significant blood granulocytosis. ...

journal_title：Archives of toxicology

authors： Giusti GV,Carnevale A

更新日期：1975-10-20 00:00:00

abstract：:Female wistar rats, conventional albino mice, and Chinese hamsters were given a single dose of acrylonitrile, 0.5 or 0.75 mM/kg body weight. The elimination in the urine of thiocyanate, which is the main metabolite of acrylonitrile, indicated a decreasing proportion of biotransformation after oral (over 20%), intraper...

journal_title：Archives of toxicology

authors： Gut I,Nerudová J,Kopecký J,Holecek V

更新日期：1975-02-14 00:00:00

abstract：:Volunteers inhaled a constant concentration of 50 ppm trichloroethylene (Tri) for 6 hrs per day on 5 consecutive days. Simultaneous ethanol (EtOH) ingestion (blood level 0.6%) inhibits the metabolization of Tri to trichloroethanol (TCE) and trichloroacetic acid (TCA) by 40% on the average. Oxidation of Tri to TCA does...

journal_title：Archives of toxicology

authors： Müller G,Spassowski M,Henschler D

更新日期：1975-01-01 00:00:00